Skip to main content
Fig. 4 | Molecular Cancer

Fig. 4

From: CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis

Fig. 4

Roles of circDOCK1 and IGF1R in vivo. A qRT–PCR detecting the mRNA level of IGF1R in OS tissues. B Western blot analysis measuring the protein level of IGF1R in OS tissues. C Positive association between circDOCK1 expression and IGF1R expression (P < 0.001). D circDOCK1 RNA expression was measured by qRT–PCR post transfection of the shRNA (normalized to sh-NC). E Subcutaneous injection of MG63 cells into nude mice. F Tumor volumes. G Tumor weights. H TUNEL assay (scale bar = 20 μm). I FISH of miR-339-3p and circDOCK1 in xenograft tumors (scale bar = 20 μm). J-K Luciferase signal intensities and H&E staining post tail vein injection in nude mice (scale bar = 100 μm). L Number of metastatic nodules in the lungs post tail vein injection. The data are presented as the mean ± SD values. **P < 0.01, ***P < 0.001

Back to article page