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Fig. 1 | Molecular Cancer

Fig. 1

From: Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin

Fig. 1

NORAD expression is increased in CDDP-resistant ESCC tissues and correlated with poor prognosis of patients. a The differential lncRNAs between chemoradiotherapy-sensitive and chemoradiotherapy-resistant ESCC in public GSE45670 dataset. b Validated expression of 5 upregulated lncRNAs in the tissues from 93 ESCC patients by using qRT-PCR. Error bars indicate SD. *** P < 0.001. c The expression of NORAD in ESCC tissues and normal esophageal tissues in TCGA database. ** P < 0.01. d Representative images of RNA FISH of NORAD in ESCC tissues (× 400), which show that NORAD is predominantly located in the cytoplasm. Nuclei are stained with DAPI. FISH score of NORAD in CDDP-resistant ESCC group was higher, compared to CDDP-sensitive ESCC group. e Kaplan-Meier analysis curves of DFS and OS for ESCC patients with high (n = 48) or low (n = 45) NORAD expression. The cut-off value was calculated by using X-tile. f ROC curves of NORAD for predicting DFS and OS in ESCC patients. g Multivariate analyses of hazard ratios for DFS and OS in ESCC patients

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Molecular Cancer

ISSN: 1476-4598