Fig. 3
From: Cancer associated-fibroblast-derived exosomes in cancer progression
Schematic presentation of exosomes in the TME. The biogenesis of exosomes mainly comprises three stages, which includes (i) the formation of early endosome by cytoplasmic membrane invagination, (ii) the formation of MVBs containing cargos-enriched ILVs, and (iii) the release of ILVs as exosomes after the fusion of MVBs with the plasma membrane