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Table 2 Examples of small molecule epigenetic modifiers

From: Epigenetic modulation of antitumor immunity for improved cancer immunotherapy

Molecule name Epigenetic target Chemical structure
Azacytidine
(5-Azacytidine)
DNMT1
Vorinostat
(SAHA)
Pan-HDAC
Romidepsin
(depsipeptide and SK228)
Class I HDACs
Chidamide
(HBI-8000)
Class I (HDAC1, 2, 3) Class IIb (HDAC10)
GSK503 EZH2
Tazemetostat EZH2
AS-8351 KDM5B (histone demethylase) inhibitor
SIRT2104 SIRT1
JQ1 BRD2, BRD3, BRD4, BRDT
Onametostat
[JNJ-64619178]
PRMT5 inhibitor