Table 2 Examples of small molecule epigenetic modifiers
From: Epigenetic modulation of antitumor immunity for improved cancer immunotherapy
Molecule name | Epigenetic target | Chemical structure |
|---|---|---|
Azacytidine (5-Azacytidine) | DNMT1 |
|
Vorinostat (SAHA) | Pan-HDAC |
|
Romidepsin (depsipeptide and SK228) | Class I HDACs |
|
Chidamide (HBI-8000) | Class I (HDAC1, 2, 3) Class IIb (HDAC10) |
|
GSK503 | EZH2 |
|
Tazemetostat | EZH2 |
|
AS-8351 | KDM5B (histone demethylase) inhibitor |
|
SIRT2104 | SIRT1 |
|
JQ1 | BRD2, BRD3, BRD4, BRDT |
|
Onametostat [JNJ-64619178] | PRMT5 inhibitor |
|
