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Fig. 3 | Molecular Cancer

Fig. 3

From: CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein

Fig. 3

circRTN4 promotes PDAC tumor growth and liver metastasis. A-C CircRTN4 knockdown in CFPAC-1 cells inhibited tumor growth. (A) tumor volume and (B) mass of mice subcutaneous xenograft after knockdown of circRTN4 at day 34. (C) Hematoxylin and eosin staining of the subcutaneous xenograft tumors. D CircRTN4 knockdown in mice subcutaneous tumors decreased the cell proliferation marker Ki67 and anti-apoptotic protein Bcl-2 level, revealed by immunohistochemical staining. E CircRTN4 knockdown in mice orthotopic tumors inhibited liver metastasis. Representative images of liver metastasis were shown. Data represent mean ± SD from at least three independent experiments (*p < 0.05; **p < 0.01; ***p < 0.001)

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Molecular Cancer

ISSN: 1476-4598