Fig. 1
From: Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
The affection of metabolic alterations on anti-tumor functions of CD8+ TILs. Metabolic alterations of CD8+ TILs mainly reflect in glycolysis and fatty acid metabolism. Reduced activity of enolase 1 and HK2 inhibits functions of CD8+ TILs through impairing glycolysis, whereas increased production of PEP promotes it. Compared with positive influence of fatty acid catabolism, fatty acid accumulation suppresses functions of CD8+ TILs. Components in Fig. 1 are drawn using tools in Biorender.com