Fig. 1
From: CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals
CircRNAs biogenesis. a After colinear splicing, the intron excised from a multi exon gene results in a 2’-5’ linked lariat that cannot be degraded but can be processed to become a stable 2’-5’circRNA. b Backsplicing process occurs when in a nascent mRNA, the 5’ end of an exon joins with its upstream 3’ end leading to the formation of a 3’-5’ exonic cirRNA. c During alternative splicing of linear mRNA, the excised exon is substrate for intralariat backsplicing leading to circRNA formation