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Fig. 6 | Molecular Cancer

Fig. 6

From: BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion

Fig. 6

Exhaustion and cytotoxicity of CD8+ T cells (n = 70). (a) Representative graphs of PD1+Tim-3+ in BCL-2+, and BCL-2− CD8+ T cells of patients with CLL. (b) Comparison of the percent positive rate and MFI of PD1+Tim-3+ in BCL-2+ and BCL-2− CD8+ T cells. (c) and (e) Representative graphs of granzyme B and perforin in CD8+BCL-2+ T and CD8+BCL-2− T cells in patients with CLL. (d) and (f) Percentage positive and MFI of granzyme B and perforin in BCL-2-positive and -negative T cells. Differences are shown in scatter plots (**p < 0.01, ***p < 0.001, ****p < 0.0001, ns, not significant)

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Molecular Cancer

ISSN: 1476-4598