Fig. 4
From: Targeting HNRNPU to overcome cisplatin resistance in bladder cancer
Knockout of HNRNPU regulated BUC progression and cisplatin sensitivity. (A) T24 cells were transfected with control sgRNA or sgHNRNPU prior to cisplatin treatment for 5 days, and cell viability was measured using CCK-8 assay. Arrows showed the error bars = 100 uM. (B) The cell cycle profiles of T24 cells with different treatments were detected by flow cytometry. Student’s t test was performed to detect the differences among treatments *: p < 0.05 **: p < 0.01(C) The apoptosis rate under the indicated treatments were examined by flow cytometry. (D) Cell migration of T24 cancer cells was determined by trans well assay. The data indicates mean ± SD from three independent experiments. (E) Photo of the isolated tumors with different treatments on day 28. (F) The tumor growth curve of different treatments, NC = negative control, KO = knockout of HNRNPU. (G) Weight of tumors in the indicated group