Fig. 8
From: Targeting HNRNPU to overcome cisplatin resistance in bladder cancer
Knockout of HNRNPU regulated the BUC cell proliferation, apoptosis, and migratory through regulating NF1 expression. T24 cells were transfected with sgHNRNPU, with or without the NF1 knockdown, and then treated with or without cisplatin. (A) T24 cell viability was measured using CCK-8 assay. (B) Cell invasion of T24 cancer cells was determined by transwell assay. (C) Cell migration of T24 cancer cells was determined by wound healing assay. (D) The cell cycle of T24 cells with different treatments were detected by flow cytometry. (E) The apoptotic rate was examined by flow cytometry. The data indicate mean ± SD from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001