Fig. 7From: Current applications and future perspective of CRISPR/Cas9 gene editing in cancerThe structure of mixed TCR dimers and the application of CRISPR/Cas9 in TCR-T cell therapy. Introduction of transgenic TCRs can cause formation of new reactive TCR dimers. Knock-out of endogenous TCRs avoids the formation of mixed TCR dimers and increases the expression of transduced TCRsBack to article page