Fig. 6

CircORC5 acted as a sponge of miR-30c-2-3p in GC. A Schematic representation of potential binding sites between circORC5 and miR-30c-2-3p. B The luciferase activity of the WT luc-circORC5 or Mut luc-circORC5 after transfection with miR-30c-2-3p mimics in MGC-803 and AGS cells. C RT-qPCR was performed to observe the effects of circORC5 knockdown or METTL14 overexpression on miR-30c-2-3p expression in the MGC-803 and AGS cells. D, E RIP for Ago2 was performed to examine the endogenous expression of circORC5 and miR-30c-2-3p in MGC-803 and AGS cells. F MTT analysis of the effect of transfection with si-circORC5 and (or) miR-30–2-3p inhibitor on the cell viability in MGC-803 and AGS cells. Data are the means ± SEM of three experiments. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001