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Fig. 7 | Molecular Cancer

Fig. 7

From: CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells

Fig. 7

In vivo study of the function of gene cdk6 to regulate drug-resistance of KB-C2 tumors. A Image of the tumors from the tumor-bearing mice showing the tumor morphology and the fluorescent DOX (depicted with yellow-green arrows) accumulated in the cdk6-present or cdk6-deficient tumors. The mice treated with saline were set as the blank control group. The tumors were sampled by the 19th day of DOX treatment. B Increased tumor sizes after the mice received chemotherapy using DOX. The mice treated with saline were set as the blank control group. C Comparison of the relative fluorescent intensity showing the difference of DOX accumulation in the cdk6-present or cdk6-deficient tumors. D Pathology of main organs of the mice bearing KB-C2 or KB-C2-k.o.cdk6 tumors. The organs were sampled by the 19th day after DOX treatment. The circle in black depicts focal infiltration of peri-bronchial inflammatory cells. The arrows in red depicts white pulp germinal center expansion, which occurred frequently in the tumor-bearing mice untreated with DOX, but only occasionally detected in the DOX-treated mice bearing KB-C2-k.o.cdk6

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Molecular Cancer

ISSN: 1476-4598