Table 5 Representing the exosomal miRNAs in biological fluids as prognostic and diagnostic biomarkers and therapeutic targets in colorectal cancer
From: Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
Exosomal miRNA | Sample Type | Role | Mechanism of action | Reference |
|---|---|---|---|---|
miR-139-3p | plasma | Diagnosis | monitoring of metastasis | Li et al. (2020) [46] |
miR-126, miR-1290, miR-23a, and miR-940 | Serum | Diagnostic | distinguish CRC at TNM stage I | Shi et al. (2021) [80] |
miR-4323, miR-4284, miR-1290, and miR-1246 | Serum | Diagnostic | CRA organoid culture | Handa et al. (2021) [81] |
miR-106b-3p | Serum | Diagnostic and prognostic | promotes metastasis by down-regulating DLC-1 expression. | Liu et al. (2020) [82] |
miR-874 | Serum | Diagnostic and prognostic | positive lymph node metastasis, poor differentiation, and advanced TNM stage. | Zhang et al. (2020) [83] |
let-7 g and miR-193a | Plasma | Diagnostic and prognostic | Accelerated cancer progression | Cho et al. (2021) [85] |
miR-106b-3p | Serum | Therapeutic target | promotes metastasis by down-regulating DLC-1 expression | Liu et al. (2020) [82] |
miR-221/222 | Serum | Therapeutic target | exacerbates tumor liver metastasis by targeting SPINT1 | Tian et al. (2021) [86] |