Table 1 Comparison of baseline characteristics of CRC cases with WT or Mutant PIK3CA status before and after propensity score matching (PSM)

Age^a (years)

62.0 (54.0-69.0)

65.0 (51.0-73.2)

0.055

59.6±14.0

63.4±13.2

0.2893

Sex

0.081

0.7961

Male

685

17

13

15

Female

403

19

17

15

Tumor location

<0.001

0.607

Rectum

577

9

6

9

Left colon

288

7

5

6

Right colon

223

20

19

15

BMI (kg/m²)

0.015

0.289

<18.5

43

5

1

4

18.5-23.9

588

17

19

14

>23.9

457

14

10

12

CEA level (U/ml)

0.323

1.000

≥5

375

11

8

7

<5

674

22

19

20

Unknown

39

3

3

3

CA199 level (U/ml)

<0.001

0.510

≥37

168

16

7

11

<37

882

17

20

16

Unknown

38

3

3

3

Tumor size^a (cm)

4.0 (3.0-5.5)

4.8 (3.0-6.0)

0.421

4.8 (4.0-6.0)

4.5 (3.1-6.0)

0.572

Histology

<0.001

0.785

Well/moderately differentiated Adenocarcinoma

901

20

21

19

Poorly differentiated Adenocarcinoma/Mucinous adenocarcinoma

187

16

9

11

T stage

0.306

0.998

T₁

50

1

0

1

T₂

219

2

0

2

T₃

695

26

24

22

T₄

124

7

6

5

Nstage

0.016

0.135

N₀

633

12

15

12

N₁

312

16

7

14

N₂

143

8

8

4

Tumor deposit

0.004

1.000

Positive

150

12

6

6

Negative

928

24

24

24

Unknown

10

0

0

0

Intravascular invasion

0.001

1.000

Positive

82

9

5

4

Negative

996

27

25

26

Unknown

10

0

0

0

Perineural invasion

0.055

1.000

Positive

109

8

5

4

Negative

969

28

25

26

Unknown

3

0

0

0