Fig. 5

Baseline biomarker results from biopsy specimens based on PFS. A Genomic events based on timing of progression following treatment (PFS event ≤ 12 versus > 12 months); asterisks indicate censoring. An exploratory forest-plot analysis of PFS according to specific somatic mutations showing unstratified hazard ratios with 95% CIs for progression. B Kaplan–Meier estimates of PFS by CD8 status and PD-L1 expression. PFS was assessed in patients with available PD-L1 staining results (n = 29). CD8 > 20% tumors were defined as CD8⁺. PFS, progression-free survival