Table 1 Clinical summary of Cohort 1 (n=230), 2 (n=115), and 3 (n=48). Cohorts 1 and 2 were sourced from BCC, and clinical characteristics are summarized for incident- (n=36, n=18), prevalent- (n=12, n=6), and no-cancer (n=182, n=91) participants. Cohort 3 was sourced from SPH/BCC and clinical characteristics are summarized for incident- (n=5), prevalent- (n=3), no-cancer (n=40) participants. Patients were randomly assisnged to Cohort 1 or 2 Values are displayed as mean values, unless otherwise specified
From: Distinct bronchial microbiome precedes clinical diagnosis of lung cancer
Cohort 1 | Cohort 2 | Cohort 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|
Incident | Prevalent | No cancer | Incident | Prevalent | No cancer | Incident | Prevalent | No cancer | |
N | 36 | 12 | 182 | 18 | 6 | 91 | 5 | 3 | 40 |
Age (mean) | 64.4 | 62.1 | 62.1 | 64.6 | 65.5 | 61.8 | 64.6 | 64.3 | 62.6 |
Sex (% female) | 44.4 | 50 | 46.2 | 50 | 83.3 | 45.1 | 40 | 66.6 | 47.5 |
Smoking status (mean %) | |||||||||
Current | 50 | 25 | 45.6 | 55.6 | 33.3 | 47.3 | 20 | 33.3 | 47.5 |
Ex | 50 | 75 | 54.4 | 44.4 | 66.7 | 52.7 | 60 | 0.0 | 52.5 |
Never | 0 | 0 | 0 | 0 | 0 | 0 | 20 | 33.3 | 0 |
Pack-years smoked (mean) | 51.1 | 48 | 47 | 55.3 | 47 | 44.8 | 50.7 | 37.8 | 48 |
Lung function (mean) | |||||||||
FEV1/FVC | 67.3 | 62 | 71.3 | 66 | 65.2 | 72.1 | 73.6 | 79 | 67 |
FEV1 | 2.5 | 2.1 | 2.6 | 2.3 | 1.8 | 2.6 | 2.3 | 2.1 | 2.4 |
FEV1 % predicted | 78.5 | 71.4 | 84.3 | 85.2 | 68.6 | 85.2 | 88 | 83.3 | 77.6 |
COPD status (mean %) | |||||||||
No COPD | 36.1 | 33.3 | 57.1 | 38.9 | 33.3 | 63.7 | 80 | 100 | 45 |
Mild | 19.4 | 8.3 | 18.1 | 16.7 | 0 | 17.6 | 0 | 0 | 5 |
Moderate | 38.9 | 25 | 20.9 | 33.3 | 33.3 | 16.5 | 20 | 0 | 35 |
Severe | 2.8 | 16.7 | 2.7 | 11.1 | 16.7 | 1.1 | 0 | 0 | 15 |
Very Severe | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Follow-up time (mean, yr) | |||||||||
Total | 9.7 | 9.5 | 10 | 10.1 | 8.4 | 10.1 | 7.6 | 7 | 9.8 |
To cancer | 4.2 | N/A | N/A | 4.3 | N/A | N/A | 1.9 | N/A | N/A |
Cancer type | |||||||||
LUAD | 42.4 | 88.9 | 38.9 | 66.7 | 100 | 100 | |||
LUSC | 12.1 | 11.1 | 16.7 | 33.3 | 0 | 0 | |||
NSCLC | 9.1 | 0 | 11.1 | 0 | 0 | 0 | |||
SCLC | 12.1 | 0 | 5.6 | 0 | 0 | 0 | |||
Other | 24.2 | 0 | 27.8 | 0 | NA | NA | |||