Clinical significance of FBXW7 loss of function in human cancers

Fan, Jingyi; Bellon, Marcia; Ju, Mingyi; Zhao, Lin; Wei, Minjie; Fu, Liwu; Nicot, Christophe

doi:10.1186/s12943-022-01548-2

Molecular Cancer

Table 4 Targets of FBXW7

From: Clinical significance of FBXW7 loss of function in human cancers

Factor	Description	Expression	References
SKP1	S-phase kinase-associated protein 1	↓	[136, 153,154,155,156,157,158,159,160,161,162,163,164,165]
SKP1	S-phase kinase-associated protein 1	↑	[135, 155, 157, 158]
MYC	v-myc avian myelocytomatosis viral oncogene homolog	↓	[166]
MYC	v-myc avian myelocytomatosis viral oncogene homolog	↑	[155, 157, 158]
CUL1	cullin 1	↓	[136, 153, 154, 158, 163, 165, 167,168,169,170,171,172,173]
CUL1	cullin 1	↑	[155, 157, 158, 174,175,176,177]
CCNE1	cyclin E1	↓	[126, 162, 163, 165, 172, 178,179,180,181,182,183,184,185,186,187,188]
NOTCH1	NOTCH 1	↓	[126, 163, 164, 180, 189,190,191,192]
NOTCH1	NOTCH 1	↑	[157, 193]
FBXW7	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	↓	[5, 126, 136, 181, 187, 189]
FBXW7		↑	[135, 157]
JUN	jun proto-oncogene	↓	[188, 191, 194, 195]
JUN	jun proto-oncogene	↑	[135]
MCL1	myeloid cell leukemia 1	↓	[5, 153, 196, 197]
SREBF1	sterol regulatory element binding transcription factor 1	↓	[187, 198, 199]
RBX1	ring-box 1, E3 ubiquitin protein ligase	↓	[153, 163, 165]
RBX1	ring-box 1, E3 ubiquitin protein ligase	↑	[157, 176]
STYX	serine/threonine/tyrosine interacting protein	↓	[136, 200]
STYX	serine/threonine/tyrosine interacting protein	↑	[136, 201]
MED13	mediator complex subunit 13	↓	[169]
MED13	mediator complex subunit 13	↑	[155, 157]
KLF5	Kruppel-like factor 5 (intestinal)	↓	[202]
MED13L	mediator complex subunit 13-like	↓	[155]
MED13L	mediator complex subunit 13-like	↑	[157, 169]
TP53	tumor protein p53	↓	[146]
TP53	tumor protein p53	↑	[175, 176]
MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase	↓	[178]
MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase	↑	[135, 155, 157, 175, 176]
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	↓	[163, 203]
NFKB2		↑	[155, 158, 204]
FBXO45	F-box protein 45	↓	[157]
FBXO45	F-box protein 45	↑	[155, 157, 175, 176]
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	↓	[191, 205]
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	↑	[135, 157]
AURKA	aurora kinase A	↓	[181, 191, 206]
HSF1	heat shock transcription factor 1	↓	[155, 207, 208]
HSF1	heat shock transcription factor 1	↑	[155]
BLM	Bloom syndrome, RecQ helicase-like	↓	[194]

List of the most common, experimentally verified, FBXW7 targets degraded by ubiquitination (https://thebiogrid.org). According to the available literature, FBXW7 can either up- or down-regulate the expression of the listed target proteins. Some cellular targets can be up-regulated and down-regulated in different cancer types or under distinct physiological conditions. References for studies which describe target degradation is listed on the right-end side

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ISSN: 1476-4598

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