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Fig. 4 | Molecular Cancer

Fig. 4

From: N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

Fig. 4

TRAF1 plays a critical role in sunitinib-resistance. A and B Tube formation assay of sunitinib-sensitive cell lines with and without TRAF1 overexpression under sunitinib treatment. C and D Tube formation assay of sunitinib-resistant cell lines with and without TRAF1 knock-down under sunitinib treatment. Representative images (up) and total number of nodes and length (below) are shown. E Correlation analysis of relative RNA expression of TRAF1 with mTOR, VEGFA, p53 and PARP. F Proteins involved in angiogenesis signaling were mediated by TRAF1. G Proteins involved in apoptotic signal pathways were mediated by TRAF1

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Molecular Cancer

ISSN: 1476-4598