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Fig. 5 | Molecular Cancer

Fig. 5

From: N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

Fig. 5

TRAF1 is modulated by m6A RNA methylation. A The m6A contents of mRNAs in 78S and 78R cells. B The m6A contents of mRNAs in OSS and OSR cells. C The m6A contents of mRNAs in CDX-S and CDX-R tissues. D and E MeRIP assays for m6A-modified TRAF1 in 78S and 78R cells. F Protein level of m6A modification–associated genes in sunitinib-sensitive/resistant cells. G The protein level of METTL14 in CDX-S and CDX-R. H The protein level of METTL14 in clinical patient samples. I and J The positive correlation of METTL14 and TRAF1 in RNA level. K The positive correlation of METTL14 and TRAF1 in protein level. L Identification of m6A abundances on TRAF1 transcripts in METTL14 knockdown cell line and control via m6A-sequence. M and N The m6A levels of TRAF1 with modulation of METTL14

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Molecular Cancer

ISSN: 1476-4598