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Fig. 8 | Molecular Cancer

Fig. 8

From: N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

Fig. 8

Targeting TRAF1 in vivo retards sunitinib-resistant RCC. A Schematic diagram of in vivo experiments. B-D Tumor volume, tumor weight and tumor growth curve of CDX models with TRAF1 overexpression, TRAF1 knockdown or its relative controls. E IHC analysis of the TRAF1 expression. F The factors associated with resistance to TKIs (left panel); Proposed model depicting regulation and role of TRAF1 in sunitinib-resistance (right panel)

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Molecular Cancer

ISSN: 1476-4598