Fig. 1
From: Targeting the RNA m6A modification for cancer immunotherapy
Overview of the m6A modification in the mRNA life cycle. â‘ The m6A methylation complex, which consists of the core methyltransferase-like protein 3 (METTL3) and its adaptors (writer), adds m6A onto target RNAs in the nucleus. â‘¡The two main demethylases (eraser), fat mass and obesity-associated protein (FTO) and alkB homolog 5, RNA demethylase (ALKBH5), erase the methylation modification in the nucleus. â‘¢ m6A is recognized by diverse readers, such as YTHDC1, HNRNPC/G, and HNRNPA2B1, that mediate various posttranscriptional processes including RNA splicing and miRNA processing in the nucleus. â‘£ In the cytoplasm, m6A binds to different specific reader proteins, such as IGF2BPs, PRRC2A, YTHDF1/2/3, and YTHDC2, that mediate the stability, translation, and decay of the mRNA. Figure created with BioRender.com