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Fig. 8 | Molecular Cancer

Fig. 8

From: The N6-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p/PGF signalling pathway

Fig. 8

Experimental hypothesis: CircALG1 relieves the inhibitory effect of miR-342-5p on PGF mRNA expression by competitively binding to miR-342-5p and promotes PGF expression to result in enhanced invasion of CRC. The high expression of METTL3 in CRC increased the m6A modification level of ALG1 pre-mRNA, and then increased the m6A modification level of cirALG1. The m6A modification of circALG1 enhances its ability to bind to miR-342-5p and promotes circALG1 ceRNA action by enhancing its stability

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Molecular Cancer

ISSN: 1476-4598