Table 3 Targeted antigens of CAR-T cells, CAR-NK cells and CAR-Ms in cancers

CD8+ T cell

CD19

Acute Lymphoblastic Leukaemia, Multiple Myeloma, B-Cell Lymphoma

[244,245,246,247]

CD20

Melanoma, Diffuse Large B-Cell Lymphoma, Non-Hodgkin Lymphoma, Burkitt Lymphoma

[247,248,249,250,251]

CD22

B Acute Lymphoblastic Leukemia, Burkitt Lymphoma

[251, 252]

CD30

Hodgkin’s Lymphoma

[253]

CD33

Acute Myeloid Leukemia

[254]

CD56

Rhabdomyosarcoma

[255]

CD70

Renal Carcinoma, B-Cell Lymphoma

[256,257,258]

CD133

Cholangiocarcinoma, Hepatocellular Carcinoma, Pancreatic Carcinomas, Colorectal Carcinomas

[259, 260]

CD138

Multiple Myeloma

[261]

CD171

Neuroblastoma

[262]

HER2

Biliary Tract Cancer, Pancreatic Cancers

[263]

EGFR

Non-Small Cell Lung Cancer, Cholangiocarcinoma, Biliary Tract Cancers, Pancreatic Carcinoma

[259, 264,265,266]

MSLN

Gastric Cancer, Pancreatic Cancer, Pleural Mesothelioma, Ovarian Carcinoma, Biliary Tract Cancer, Tubal Cancer, Esophageal Cancer, Cervical Cancer, Triple-Negative Breast Cancer

[189, 267,268,269,270]

LMP1

Lymphoma, Nasopharyngeal Carcinoma

[271, 272]

FR-α

Ovarian Carcinoma, Colorectal Carcinomas, Pancreatic Cancer, Lung Cancer

[273]

EGFRIII

Glioblastoma

[274, 275]

GPC3

Hepatocellular Carcinoma, Pancreatic Carcinoma, Ovarian Carcinoma

[276, 277]

PSCA

Chronic Myelogenous Leukemia, Gastric Cancer

[278, 279]

MUC1

Lung Cancer, Seminal Vesicle Cancer,

[280, 281]

MAGE-A1/3/4

Lung Adenocarcinoma

[282]

EPCAM

Chronic Myelogenous Leukemia, Breast Cancer, Lung Cancer, Acute Myeloid Leukemia, Colorectal Cancer

[283,284,285,286]

PSMA

Prostate Cancer

[287]

AXL

Breast Cancer

[288]

MUC16

Ovarian Cancer

[289]

DR5

B-Cell Malignancies

[290]

c-MET

Hepatocellular Carcinoma, Gastric Cancer, Renal Cell Carcinoma

[291,292,293]

BCMA

Multiple Myeloma

[294,295,296]

GPC3

Hepatocellular Carcinoma

[297]

CS1/SLAMF7

Multiple Myeloma,

[298]

NKG2D

Hepatocellular Carcinoma, Glioblastoma

[299, 300]

CLL-1

Acute Myeloid Leukemia

[301, 302]

CEA

Colorectal Cancers, Pancreatic Malignancy, Hepatocellular Carcinoma

[270, 303, 304]

NK cell

CD5

T Cell Malignancies

[305]

CD7

Lymphoma, Leukemia

[306]

CD19

Acute Lymphoblastic Leukaemia, Chronic Lymphocytic Leukemia, B Lymphoblastoid, Monocytic Leukemia, Ovarian Cancer, Chronic Myelocytic Leukemia, Breast Cancer, Lung Cancer, Gastric Cancer, Epidermoid Carcinoma, Bladder Cancer

[201, 307, 308] [309,310,311]

CD20

B-Cell Malignancies, Burkitt Lymphoma

[312, 313]

CD33

Acute Myeloid Leukemia.

[314]

CD38

Acute Myeloid Leukemia.

[315]

CD123

Acute Myeloid Leukemia, Blastic Plasmacytoid Dendritic Cell Neoplasm

[316,317,318]

CD138

Multiple Myeloma

[319]

CS1

Ovarian Cancer, Multiple Myeloma

[320, 321]

EBNA3C

Leukemia

[322]

EGFRvIII

Glioblastoma

[323]

EPCAM

Breast Carcinoma

[324]

GD2

Neuroblastoma, Ewing Sarcomas,

[325, 326]

GPA7

Melanoma

[327]

GPC3

Ovarian Cancer

[328]

HER-2

Glioblastoma, Breast Cancer, Renal Cell Carcinoma

[329,330,331]

HLA-A2

Melanoma

[327]

HLA-DR

Glioblastoma

[332]

HLA-G

Leukemia

[333]

MSLN

Ovarian Cancer

[334]

PSCA

Ladder Carcinoma

[335]

Macrophage

HER2

Chronic Myelocytic Leukemia

[309]

MSLN

Chronic Myelocytic Leukemia

[309]