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Table 2 Univariate and multivariate analyses of overall survival in PDAC patients (n = 97)

From: CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2

Variables Univariable analysis Multivariable analysis
  HR 95%CI P value HR 95%CI P value
Gender (Female vs. Male) 0.838 0.470–1.494 0.549    
Age (≥ 60y vs. < 60y) 1.071 0.562–2.041 0.834    
Location (Body + tail vs. Head) 0.635 0.344–1.171 0.146    
Tumor_differentiation (G3 vs. G1 + G2) 1.015 0.578–1.781 0.96    
TNM stage (III + IV vs. I + II) 1.479 0.846–2.588 0.17    
T stage (T3 + T4 vs. T1 + T2) 1.882 1.086–3.262 0.024* 1.621 0.870–3.021 0.128
 N stage (N1 + N2 vs. N0) 1.022 0.593–1.761 0.939    
Nerve invasion (Yes vs. No) 2.038 0.634–6.549 0.232    
Major vascular invasion (Yes vs. No) 1.907 0.957–3.801 0.067 1.363 0.633–2.936 0.428
Serum CA19_9 (≥ 37U/ml vs. < 37U/ml) 1.442 0.615–3.380 0.399    
CircSTX6 expression (High vs. Low) 2.025 1.162–3.528 0.013* 3.013 1.655–5.486 < 0.001***
miR-449b-5p expression (High vs. Low) 0.47 0.269–0.820 0.008** 0.426 0.232–0.780 0.006**
  1. HR hazard ratio, CI confidence interval, TNM tumor node metastasis. Cox regression analysis, *p < 0.05, **p < 0.01, ***p < 0.001