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Fig. 1 | Molecular Cancer

Fig. 1

From: circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop

Fig. 1

circEXOC6B is downregulated in CRC tissue. A The relative expression levels of circEXOC6B in CRC tissues (Cancer, n = 78) and the adjacent noncancerous tissues (Normal, n = 78) were determined by RT-qPCR. B The expression of circEXOC6B was negatively correlated with tumor size, lymphatic metastasis, and TNM stage. C RT-qPCR showed the expression of circEXOC6B was lower in 15 cases of cancer tissues than in the matched adjacent tissues in the colon cancer cDNA microarray. D Kaplan-Meier survival analysis revealed that the patients with high circEXOC6B expression had a higher OS rate than patients with low circEXOC6B expression. E and F Forest plots of the univariate and multivariate Cox proportional hazards model verified the prognostic value of circEXOC6B

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Molecular Cancer

ISSN: 1476-4598