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Fig. 4 | Molecular Cancer

Fig. 4

From: circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop

Fig. 4

circEXOC6B suppresses the mTORC1 pathway. A Western blot results showed that overexpression of circEXOC6B suppressed the mTORC1 pathway. B Knockdown of circEXOC6B activated the mTORC1 pathway. C IHC indicated that p-mTOR and HIF1A expression was upregulated in the subcutaneous tumors with stable silencing of circEXOC6B expression. Scale: 20 μm. D Western blot results showed that the p-mTOR, p-S6K, and HIF1A elevation caused by RRAGB could be reversed by co-transfection with circEXOC6B. E EdU, F CCK8, G Colony formation assays showed that the enhanced proliferation and clonogenicity of CRC cells induced by RRAGB could be rescued by overexpression of circEXOC6B. Scale: 50 μm

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Molecular Cancer

ISSN: 1476-4598