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Fig. 3 | Molecular Cancer

Fig. 3

From: CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA

Fig. 3

Knockdown of circEZH2 attenuates CRC cell proliferation and migration in vitro. A The schematic illustration of small hairpin RNAs (shRNAs) specifically targeting the back-splice junction sequences of circEZH2. B qRT-PCR analysis of circEZH2 and circEZH2 mRNA in HCT116 and SW620 cells treated with negative control (NC) or circEZH2 shRNAs. C-G CCK-8, plate colony-formation, EdU incorporation, wound-healing and transwell assays were performed to determine the proliferation and migration abilities of negative control (NC) and circEZH2-depleted (circEZH2 shRNAs) HCT116 and SW620 cells. Data were showed as mean ± SD. **P < 0.01

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Molecular Cancer

ISSN: 1476-4598