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Fig. 6 | Molecular Cancer

Fig. 6

From: Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance

Fig. 6

CircRNAs affect m6A modification in cancer therapeutic resistance. CircRNAs modulate the expression of or interact with m6A regulators, thereby influencing m6A functions in multiple cancers. (1) In glioma: circ_0072083 promoted ALKBH5 expression, leading to temozolomide resistance. (2) In CRC: circPTK2 elevated YTHDF1 level, resulting in 5-FU and oxaliplatin resistance. (3) In HCC: circRHBDD1 recruited YTHDF1, leading to anti-PD-1 therapy resistance. (4) In BC: circ0008399 facilitated the formation of MTC through combining with WTAP, thereby elevating cisplatin resistance. Furthermore, circMORC3 promoted cisplatin resistance by interacting with VIRMA. (5) In prostate cancer: circARHGAP29 interacted with IGF2BP2, thus augmenting docetaxel resistance

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Molecular Cancer

ISSN: 1476-4598