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Fig. 6 | Molecular Cancer

Fig. 6

From: CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling

Fig. 6

circSMARCC1 promotes PCa tumorigenesis and metastasis in vivo. A Images of subcutaneous xenograft tumors derived from DU145 cells transfected with vector and circSMARCC1. B Tumor weight comparison in lv-circ group and vector group. C Tumor volumes measured once a week and the growth curves were drawn. D Fluorescence image of metastatic transplanted tumor from PC-3 cells transfected with vector or circSMARCC1. E H&E staining of subcutaneous xenograft tumors in mice (scale bar, 100 μm and 20 μm). F H&E staining of metastatic lung tumors in mice (scale bar, 100 μm and 20 μm). G RNA-FISH experiment showed the fluorescence area in xenograft tumor tissues of vector and lv-circSMARCC1 groups (scale bar, 100 μm and 20 μm). H, I The expression of Ki-67 and CCL20 in xenograft tumors detected by IHC (scale bar, 100 μm and 20 μm). *p < 0.05, ***p < 0.001, ****p < 0.0001

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Molecular Cancer

ISSN: 1476-4598