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Fig. 4 | Molecular Cancer

Fig. 4

From: A two-stage genome-wide association study to identify novel genetic loci associated with acute radiotherapy toxicity in nasopharyngeal carcinoma

Fig. 4

Gene mapping and LD analysis of rs6711678, rs4848597, rs4848598, rs2091255, and rs584547. A The regional plot for rs6711678, rs4848597, rs4848598, rs2091255, and rs584547. The regional plots were constructed using LocusZoom. P values (−log10(P values); y axis) were plotted against the respective chromosomal position of each SNP (x axis). Colors indicate LD (r2) with four SNPs in 1000 Genomes Project East Asian populations. B The haplotype block of four SNPs in chromosome 2. The genomic positions were indicated. C 3D chromatin interaction and eQTL analysis of rs6711678, rs4848597, rs4848598, and rs2091255. Circos plot showing genes on chromosome 2 interacted with four SNPs by 3D chromatin interaction (orange line) and eQTL mapping (green line). The outer layer showed the –log10(P values) of four SNP in the GWAS analysis

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Molecular Cancer

ISSN: 1476-4598