Fig. 1
From: The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer
The composition and function of m6A modification. The m6A modification is installed by writers, including METTL3, METTL14, WTAP, RBM15, VIRMA and METTL16. FTO and ALKBH5 are m6A erasers that remove m6A modifications. Readers are required to recognize m6A and exert post-transcriptional regulation. Writers, erasers, and readers synergistically regulate RNA splicing, export, translation, decay, and stability