Fig. 4
From: The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer
The upstream region of METTL14. KDM5C inhibits histone H3K4me3 and decrease METTL14 mRNA expression. The transcription factor SPI1 and HIF1α and RNA binding protein HuR inhibit METTL14 mRNA expression, while p65 and FOXO3a promote METTL14 mRNA expression. The SPI1, HuR and p65 can directly bind to the promoter of METTL14, however, the regulation mechanism of FOXO3a and HIF1α on METTL14 need to be further explored. In addition, CLK1 and SRSF5 can control METTL14 exon10 skipping. Moreover, TCF4 can inhibits ubiquitination of METTL14 and increases its expression. HRD1 is an E3 ubiquitin ligase of METTL14 and can promote ubiquitination of METTL14 and decreases its expression