Table 1 Role of METTL14 in gastrointestinal cancer
From: The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer
Cancer type | Role | Target | Upstream | Reader | Functions |
|---|---|---|---|---|---|
HCC | Tumor suppressor | EGFR PI3K/AKT | Suppresses migration and invasion [111] | ||
Tumor suppressor | miR-126 | Suppresses metastasis [92] | |||
Tumor suppressor | SLC7A11 | HIF-1α | YTHDF2 | Suppresses hypoxia blocked-ferroptosis [112] | |
Tumor suppressor | USP48 SIRT6 | Attenuate glycolysis and malignancy [113] | |||
Tumor suppressor | HNF3γ | Suppresses proliferation and sorafenib resistance [103] | |||
Oncogene | ACLY SCD1 | Promotes FA synthesis and lipid accumulation [114] | |||
CRC | Tumor suppressor | miR-375 YAP1/SP1 | Suppresses migration, invasion, proliferation [94] | ||
Tumor suppressor | KLF4 | IGF2BP2 | Suppresses migration and invasion [115] | ||
Tumor suppressor | ARRDC4 | HuR TCF4 | YTHDF2 | Suppresses metastasis [83] | |
Tumor suppressor | SOX4 | KDM5C H3K4me3 | YTHDF2 | Suppresses metastasis [116] | |
Tumor suppressor | LincR XIST | YTHDF2 | Suppresses proliferation and metastasis [93] | ||
Tumor suppressor | miR-149-3p | Suppresses inflammation and malignancy [110] | |||
Tumor suppressor | IFN-c/ STAT1/IRF1 | YTHDF2 | Promotes immune responses to anti-PD-1 therapy [108] | ||
Tumor suppressor | EBI3 | Promotes antitumor response and CD8 + T cell infiltration [109] | |||
Tumor suppressor | ANKLE1 | YTHDF1 | Suppresses proliferation, and colony formation [117] | ||
Oncogene | PHLDB2 | Promotes Cetuximab Resistance [105] | |||
GC | Tumor suppressor | circORC5 | Suppresses proliferation and invasion [118] | ||
Tumor suppressor | Wnt/ PI3K‐Akt | Suppresses proliferation and invasion [119] | |||
Tumor suppressor | PI3K/AKT/ mTOR | Suppresses proliferation and invasion [120] | |||
Oncogene | LINC01320 | Promotes migration, invasion, proliferation [121] | |||
PC | Oncogene | PERP | Suppresses growth and metastasis [91] | ||
Oncogene | CDA | P65 | Promotes gemcitabine resistance [122] | ||
Oncogene | AMPKα/ ERK/mTOR | Suppresses apoptosis and autophagy [101] | |||
Tumor suppressor | PIK3CB | YTHDF2 | Suppresses proliferation and invasion [123] | ||
Tumor suppressor | CLK1 SRSF5 | Suppresses proliferation and metastasis [96] |