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Fig. 3 | Molecular Cancer

Fig. 3

From: S6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer

Fig. 3

Elevated expression of S6K1 is related to palbociclib resistance in the validation patient cohort. A The expression of S6K1 in patients with breast cancer was detected by immunohistochemistry (IHC). High S6K1 expression (positive score 6-8) was observed in 15/104 (14%) of patients. B Kaplan–Meier curves for PFS in the validation patient cohort who had received palbociclib treatment according to S6K1 expression. P value was calculated by log-rank test. C Copy number variation profiles for the S6K1 loci using droplet digital PCR (ddPCR). D Representative images showing multiplex immunofluorescence (multi-IF) stanning of tissue samples from patients with high or low S6K1 expression. E The expression of S6K1 had a high correlation with cyclin E1 and p-Rb based on the results of multi-IF in the patient with high S6K1 expression. F The proportion of p-Rb + S6K1+ cells and cyclin E1 + S6K1+ cells in patients with high or low S6K1 expression. Data are represented as the mean ± SD. P value was calculated by Mann-Whitney test. ****, P < 0.0001

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Molecular Cancer

ISSN: 1476-4598