Fig. 1From: The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategiesOverview of the effects of hypoxia on tumor cells. Hypoxia contributes to many critical aspects of cancer, including genome instability, autophagy, metabolic reprogramming, angiogenesis, migration, invasion, extracellular matrix remodeling, epithelial mesenchymal transition (EMT), stem cell maintenance, immune evasion and therapy resistanceBack to article page