Fig. 4From: The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategiesMechanisms of action of the HIF inhibitors currently on the market or under clinical trials. HIF inhibitors target HIF on different levels, ranking from transcription, translation, protein stabilization, transcriptional coactivators recruitment, and dimerization. The clearance of ROS leads to decreased HIF-α stabilization and accumulationBack to article page