Fig. 6

The MM malignant clonal evolution reprogramming tumor microenvironment mediates tumor heterogeneity in patients. A Patient-specific transcriptional patterns of MM malignant subclones. B Malignant subclonal self-organization contribution of specific marker genes in MM patients. C Patient-specific transcriptional patterns of MM BM microenvironment cells. D Lymphocyte subsets of the BM microenvironment of control donors and MM patients. The atlas involves B cells, plasma cells, CTLs, T cells, and NK cells. Left: Single-cell subpopulation atlas of each cell type. Middle: Proportion of each cell subgroup in the control donor and different MM patients. Right: Expression pattern of cell subgroup-specific markers mapped in the single-cell atlas. E Atlas of myeloid cell subsets in the BM microenvironment of control donors and MM patients. The atlas involves classical dendritic cells (cDCs) and monocyte cells. Left: Single-cell subpopulation atlas of the cell type. Middle: Proportion of each cell subgroup in the control donor and different MM patients. Right: Expression pattern of cell subgroup-specific markers mapped in the single-cell atlas. F Expression patterns of lymphocyte subset-specific markers and the biological signals involved. G Expression patterns of myeloid cell subset-specific markers and the biological signals involved. CTL, cytotoxic T lymphocytes; MM, multiple myeloma; BM, bone marrow