Fig. 4
From: Targeting RNA N6-methyladenosine modification: a precise weapon in overcoming tumor immune escape
Overview of the regulation of tumor immune escape-associated glycolytic enzymes by N6-methyladenosine modification in tumor cells. The afferent blood delivers glucose to tissues, where it reaches the cells by diffusion. Glucose is taken up by specific glucose transporters (GLUTs), which are first converted to glucose-6-phosphate by hexokinase (HK) and then to pyruvate by various enzymes, including glucose phosphate isomerase (GPI), phosphofructokinase (PFK), aldolase (ALDO), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), phosphoglycerate mutase (PGM), enolase (Eno), pyruvate kinase (PK), pyruvate dehydrogenase (PDH), and lactate dehydrogenase (LDH). ALDO, aldolase; Eno, enolase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GLUT, glucose transporter; GPI, glucose phosphate isomerase; HK, hexokinase; LDH, lactate dehydrogenase; PDH, pyruvate dehydrogenase; PFK, phosphofructokinase; PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase; PK, pyruvate kinase