Targeting RNA N6-methyladenosine modification: a precise weapon in overcoming tumor immune escape

Li, Wei; Hao, Yi; Zhang, Xingda; Xu, Shouping; Pang, Da

doi:10.1186/s12943-022-01652-3

Molecular Cancer

Table 1 m⁶A modification promote TIE by activating β-catenin signaling pathway

From: Targeting RNA N⁶-methyladenosine modification: a precise weapon in overcoming tumor immune escape

Regulator	Cancer	Mechanism	Functions	Refs.
METTL3	CRC	Stabilizes Sec62.	Promotes stemness and chemoresistance of CRC cell by activating β-catenin pathway.	[71]
METTL3, METTL14, FTO, ALKBH5	HCC	Stabilizes circRNA-SORE.	Induces sorafenib resistance of HCC by activating β-catenin pathway.	[72]
METTL3	hepatoblastoma	Promotes CTNNB1 stability.	Promotes proliferation and colony-forming ability of hepatoblastoma cell by activating β-catenin pathway.	[73]
METTL3	hepatoblastoma	Promotes β-catenin expression.	Promotes hepatoblastoma cell proliferation, invasion, and migration by activating β-catenin pathway.	[74]
METTL3	melanoma	Promotes UCK2 stability.	Promotes melanoma cell invasion by activating β-catenin pathway.	[75]
METTL3	NPC	Stabilizes Tankyrase.	Promotes NPC cell migration and invasion by activating β-catenin pathway.	[76]
METTL3	EC	Promotes APC degradation.	Promotes aerobic glycolysis, proliferation, and tumor formation in mice by activating β-catenin pathway.	[77]
METTL3	osteosarcoma	Promotes LEF1 stability.	Promotes osteosarcoma cell proliferation, migration, and invasion by activating β-catenin pathway.	[78]
METTL3	NPC	Promotes TRIM11 stability.	Enhances the chemoresistance by activating β-catenin pathway.	[79]
FTO	CC	Upregulates β-catenin.	Promotes chemo-radiotherapy resistance by upregulating β-catenin.	[80]
ALKBH5	glioblastoma	Promotes SOX2 expression.	Promotes glioblastoma cell proliferation, inhibits apoptosis and temozolomide sensitivity by activating β-catenin pathway.	[81]
YTHDF1	GC	Promotes FZD7 translation.	Promotes GC cell proliferation and tumorigenesis via β-catenin pathway.	[82]
YTHDF1	CRC	Promotes TCF7L2/TCF4 translation.	Promotes intestinal stem cell stemness via β-catenin pathway.	[83]
YTHDF1	HCC	Promotes FZD5 translation.	Promotes HCC cell proliferation and metastasis via β-catenin pathway.	[84]
YTHDF2	HCC	Promotes lncAY expression.	Promotes HCC cell proliferation and migration via β-catenin pathway.	[85]
YTHDF2	LC	Promotes AXIN1 decay.	Promotes LC cell proliferation and metastasis via β-catenin pathway.	[86]

Abbreviations: CC cervical cancer, CRC colorectal cancer, EC esophageal cancer, GC gastric cancer, HCC hepatocellular carcinoma, LC lung cancer, NPC nasopharyngeal cancer

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