Targeting RNA N6-methyladenosine modification: a precise weapon in overcoming tumor immune escape

Table 3 Inhibitors of m⁶A regulators in cancer treatment

Drugs	Regulator	Cancer	Function	Refs.
Rhein	FTO	BC	Suppresses tumor growth of BC in vivo.	[183, 184]
Rhein	FTO	BC	Augments antiproliferative effects of atezolizumab based on BC regression.	[185]
MA2	FTO	glioblastoma	Inhibits GSCs growth and self-renewal in vitro, and tumor growth in vivo.	[137, 186]
MA2	FTO	glioblastoma	Enhances the effect of the chemotherapy drug temozolomide on suppressing proliferation of glioma cells.	[187]
MO-I-500	FTO	BC	Inhibits the survival and/or colony formation of a triple-negative inflammatory BC cell line.	[188,189,190]
FB23-2	FTO	AML	Suppresses proliferation and promotes the differentiation/apoptosis of AML cells and in vitro, and inhibits tumor growth in vivo.	[191]
R-2HG	FTO	AML	Inhibits cell growth, promotes cell cycle arrest and apoptosis of leukemia cells.	[192]
CS1	FTO	AML, BC, PC, and glioblastoma	Suppresses CSC maintenance and immune evasion of AML.	[39]
CS2	FTO	AML, BC, PC, and glioblastoma	Suppresses CSC maintenance and immune evasion of AML.	[39]
BTYNB	IGF2BP1	LC, OC	Inhibits proliferation and anchorage-independent growth of IGF2BP1-positive cancer cells. Blocks tumor cells’ growth and spread in xenograft tumors. Synergizes with palbociclib at low concentrations of both compounds.	[193, 194]
STM2457	METTL3	AML	Inhibits AML cells growth and promotes differentiation and apoptosis in vitro, and disrupts engraftment and prolonged survival in vivo.	[195]

Abbreviations: AML acute myeloid leukemia, BC breast cancer, CSC cancer stem cell, GSC glioblastoma stem cell, LC lung cancer, MA meclofenamic acid, OC ovarian cancer, PC pancreatic cancer, R-2HG R-2-hydroxyglutarate

ISSN: 1476-4598