Skip to main content
Fig. 3 | Molecular Cancer

Fig. 3

From: The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition

Fig. 3

circEZH2 accentuates tumorigenesis and liver metastasis of BC cells in vivo. a Pictures of xenograft tumors were shown in the circEZH2 overexpression group and relative control group (n = 4). b The growth curves of each group of xenograft tumors were displayed. c The xenograft tumor weight was measured and analyzed. d and e Inferior hemi-spleen implantation mice models in vivo were analyzed by IVIS to identify the potential of circEZH2 in promoting liver metastasis. f and g Metastatic sites in the liver were noted to be increased in the overexpressed circEZH2. On the H&E staining liver slides, metastases were marked with arrows. (Magnification, X4 scale bar 200 μm; X20 scale bar 40 μm). The data was displayed as the mean ± SD and all experiments were repeated at least three times, **P < 0.01, ***P < 0.001

Back to article page

Molecular Cancer

ISSN: 1476-4598