Fig. 2

MIAC expression inhibits the growth and metastasis of RCC in vitro and in vivo. A The relative expression of MIAC in normal kidney cell and RCC cell lines. B Verification of overexpressed MIAC in A498 cells. C, D MIAC inhibits RCC cell proliferation by CCK8 and cell Trace CFSE assays. E MIAC inhibits RCC cell migration. F MIAC promotes RCC cell cycle arrest. G, H MIAC promotes RCC cell apoptosis. I Tumor volume in the mouse xenografts injected with A498 cells after the stable overexpression of MIAC (n = 4). J The lung metastasis of the tumor is detected by intravital imaging (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001