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Fig. 4 | Molecular Cancer

Fig. 4

From: Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma

Fig. 4

AQP2 is downregulated in RCC tissue and inbihits RCC cell proliferation and migration. A Relative expression of AQP2 in RCC samples from the TCGA database. B, C The relative expression levels of AQP2 in RCC tissues and the adjacent noncancerous tissues were determined by RT-qPCR. D, E The protein expression of AQP2 in RCC samples by Western blot and IHC assay. F Verification of overexpressed AQP2 in A498 cells. AQP2 inhibits RCC cell growth (G, H) and migration (I). AQP2 promotes RCC cell apoptosis (J, K) and cell cycle arrest (L). *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598