Fig. 6

Current combinations of ICI with targeted therapies directed against tyrosine kinase pathways. Circos plot visualising the frequency of combining specific ICI with inhibition of (receptor) tyrosine kinase signaling pathways in current clinical trials (as listed on https://clinicaltrials.gov). The width of the bands is proportional to the number of corresponding combinations. The absolute number of trials for each target is shown on the inner ring, and the relative distribution across all combinations for a specific target is depicted on the outer ring. For information on the specific malignancies included in these trials, refer to Table 1