Fig. 1

The phenotypes of PMN-MDSCs and M-MDSCs. In mice, PMN-MDSCs are defined as CD11b⁺Ly6G⁺Ly6C^lo, and M-MDSCs are defined as CD11b⁺Ly6G⁻Ly6C^hi. Human PMN-MDSCs are defined as CD11b ⁺ CD14⁻ CD15⁺ or CD11b⁺ CD14 ^- CD66b⁺, and human M-MDSCs are defined as CD11b⁺ CD14⁺ HLA-DR^−/low CD15⁻. In addition, several other markers have been associated with the MDSCs phenotype, such as CD49d, LOX1 and IL-4Rα