Fig. 2From: Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapyThe origin of MDSCs. MDSCs are derived from HSCs, common myeloid progenitors (CMPs) and granulocyte–macrophage progenitors (GMPs). GMPs then differentiate into granulocyte progenitors (GPs) and monocytic progenitors (MPs). In response to multiple tumor-induced cytokines, MDSCs were developed through signaling pathways such as STAT3, IRF8 and C/EBPβBack to article page