Fig. 5From: Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapyThe mechanisms by which MDSCs inhibit T-cell antitumor immunity. MDSCs exert their T-cell suppression mainly via the high expression of ARG1 and iNOS and the production of ROS. In addition to biochemical metabolism, MDSCs also induce immunosuppression by upregulating PD-L1 expression and secretion of TGF-βBack to article page