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Fig. 3 | Molecular Cancer

Fig. 3

From: CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment

Fig. 3

CREB3L1 knockdown decreased metastasis and tumor growth of ATC in vivo. A Schematic diagram of the experimental procedure. DiI-labeled 8505C cells (red) were implanted into the perivitelline space of each zebrafish. B The zebrafish xenograft model was employed to evaluate the metastatic ability of 8505C cells, after CREB3L1 knockdown. C-D CREB3L1 knockdown slowed tumor growth in nude mice with ATC xenografts. E–F CREB3L1 knockdown inhibited tumor metastasis in nude mice with intravenous injection of 8505C cells. G H&E staining revealed the ATC metastases (dotted-line circle) in the lung tissues. Data are shown as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 NC versus CREB3L1-KD

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Molecular Cancer

ISSN: 1476-4598