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Fig. 5 | Molecular Cancer

Fig. 5

From: CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment

Fig. 5

Single-cell RNA-sequencing revealed the role of CREB3L1 and downstream ECM signaling in ATC progression. A The UMAP plot of 16 cell subsets. B Expression, abundance, and positive ratio of CREB3L1 in different cell subsets. C Clustering results of thyroid follicular and cancer cells. D Proportion of different cell subsets in each group. E Expression and distribution of CREB3L1 in thyroid follicular cells and cancer cells. F Gene set variation analysis (GSVA) was used to calculate the activity of the ECM and collagen signaling in each cell. G Trajectory analysis of thyroid follicular and cancer cells. (H) Expression trends of CREB3L1, and the ECM and collagen signaling along the trajectory of ATC formation

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Molecular Cancer

ISSN: 1476-4598